Importance of pre-test genetic counselling in couples undergoing assisted reproductive techniques (ART) and preimplantation genetic testing (PGT)

Abstract

Seven embryo biopsies from a 33 female and 39 male year-old couple were sent for PGD, all resulted in aneuploid embryos. When analysing the case, we notice that the male had a previous 15-year-old daughter and several semen analyses with fluctuating teratozoospermia from 29% to 100%. Although ICSI and PGD are powerful tools in male factor infertility, it is not recommended in all cases, especially the ones that may be due to reversible causes. Male infertility should be evaluated thoroughly and accompanied by proper genetic studies and genetic counselling so that the couple is offered options suitable for their medical conditions and economy.